synthesis and antioxidant evaluation of some novel ortho-hydroxypyridine-4-one iron chelators
نویسندگان
چکیده
a series of ortho -hydroxypyridine-4-ones were prepared in high yields and evaluated for antioxidant and iron chelating activities. n 1 -h hydroxypyridinones va , vb , and ve were the best radical scavengers in dpph free radical scavenging assay. compound vb was proved to be the most potent compound in hydrogen peroxide scavenging assay. all of the synthesized compounds had very close chelating ability, compounds containing n 1 -ch 3 hydroxypyridinone ring were stronger chelating agents.
منابع مشابه
Synthesis and antioxidant evaluation of some novel ortho-hydroxypyridine-4-one iron chelators
A series of ortho-hydroxypyridine-4-ones were prepared in high yields and evaluated for antioxidant and iron chelating activities. N(1)-H hydroxypyridinones Va, Vb, and Ve were the best radical scavengers in DPPH free radical scavenging assay. Compound Vb was proved to be the most potent compound in hydrogen peroxide scavenging assay. All of the synthesized compounds had very close chelating ab...
متن کاملsynthesis and characterization of some macrocyclic schiff bases
ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...
15 صفحه اولDesign, synthesis, physicochemical properties, and evaluation of novel iron chelators with fluorescent sensors.
The synthesis of a range of novel 3-hydroxypyridin-4-ones and 3-hydroxypyran-4-ones linked with different coumarin substituents is described. These compounds have been developed in order to provide a series of molecular probes for the quantification of intracellular labile iron pools. An evaluation of the effect of iron(III) on fluorescence intensity was undertaken. Chelation of iron(III) cause...
متن کاملTheoretical evaluation of medicinal properties for some of N-aryl-3-hydroxypyridine-4-ones derivative compounds
Today, the bidentate ligands 3-hydroxypyridin-4-ones (HPOs) as orally active iron chelating agents have been demonstrated to possess potential for treatment of some human diseases such as iron-overload in thalassaemic patients and malaria. In this research, a series of HPOs with different substitutes and position were theoretically invest
متن کاملpreliminary mlr studies of antimicrobial activity of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives
quantitative structure-activity relationship (qsar) studies of a series of substituted 3-hydroxy-pyridine-4-ones and 3-hydroxy-pyran-4-ones as antibacterial and antifungal agents against a variety of microorganisms were performed. multiple linear regression approach was used as variable selection method. the antimicrobial activities of these compounds against staphylococcus aureus, aspergilus n...
متن کاملSynthesis, In Vitro Evaluation of Some Novel Quinazolin- 4(3H)-one Derivatives as Anti-Tumor Agents
In an effort to develop anticancer agents, a series of Mannich bases were prepared by Mannich reaction. When one biologically active molecule is linked to another, the resultant molecule generally has increased potency. Hence two pharmacophores, i.e. quinazoline ring and amine moiety are fused to obtain highly potent, more specific and less toxic agent. In the present study, synthesis of novel ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۳، صفحات ۱۷۱-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023